Wilkinson also starts ahead of Flood and Wigglesworth is a surprise starter ahead of Leicester's Ben Youngs.
Click read more to view the full side to face Argentina.
England: Ben Foden, Chris Ashton, Manu Tuilagi, Mike Tindall (captain), Delon Armitage, Jonny Wilkinson, Richard Wigglesworth, Andrew Sheridan, Steve Thompson, Dan Cole, Louis Deacon, Courtney Lawes, Tom Croft, James Haskell, Nick Easter.
Replacements: Dylan Hartley, Matt Stevens, Tom Palmer, Tom Wood, Ben Youngs, Toby Flood, Matt Banahan.
09:30BST Saturday 10th September ITV 1 - England v Argentina.